You can find more detail on B12 treatment timelines and schedules
Sharma R, Biedenharn KR, Fedor JM, Agarwal A
The FDA only endorses prescription medications for insomnia like Ambien, as well as over-the-counter medications, which often are just variations of the same two active ingredients: doxylamine and diphenhydramine

"I don't think it's working" Possible causes: Dose too low (most common) Solution: Increase by 25-50% Nasal absorption variable May need higher end of dosing range Poor technique Solution: Review technique above Head position critical Not sniffing hard Alternating nostrils Swallowing too much Solution: Keep head forward Wait longer between sprays Don't swallow for 2-3 minutes after Peptide not suitable for nasal Solution: Switch to injection Some peptides don't work nasally Try injection for comparison Degraded peptide Solution: Check storage, expiration Refrigerate always Use within 28-30 days Nasal irritation or burning Causes and solutions: High concentration: Too concentrated = irritation Solution: Dilute to lower concentration Balance between volume and concentration 5-10mg/ml usually tolerable Improper pH: Very acidic or basic = burning Solution: pH buffer (advanced) Or: Buy from reputable source with proper formulation DIY risks this issue Allergic reaction: Rare but possible Solution: Discontinue use Try different peptide Consider injection instead Nasal congestion: Congested nose = poor absorption Solution: Clear nose first Saline spray 10 minutes before (optional) Or skip dose if severely congested Dripping or running nose Causes: Too much volume at once Head tilted wrong Solution dripping from nose or throat Solutions: Use less volume per spray Perfect head position (slightly forward) Wait longer between sprays Reduce total volume (higher concentration) Wipe nose after dosing (normal) Nasal spray vs injection: The honest comparison Making the informed choice

Interstitial Cystitis A pilot study assessed the safety and efficacy of BPC 157 for interstitial cystitis in 12 women who had not responded to conventional therapies
Studies in rodent models report enhanced angiogenesis linked to upregulation of VEGFR2 and activation of downstream Akt-eNOS signalling in vascular endothelial cells