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Not every patient will benefit, and those who do will benefit in different ways depending on their diagnoses, BMI, and which program they qualify for
Dahl, C
However, if you were a true non-responder to Saxenda (no appetite change, no weight loss despite proper adherence), you might still respond to semaglutide, but response isnt guaranteed
It also provides a notable amount of calcium, which may be a bonus if you arent getting enough
GLP-1RAs may also have effects on a transcriptional level via protein kinase A (PKA), phosphorylating cAMP-response element-binding protein (CREB) in the nuclear membrane to enhance preproinsulin transcription [28]
And if you genuinely experience zero appetite change after eight or more weeks of consistent dosing, talk to your provider about whether the medication or dosing needs adjustment
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