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Obesity can be prevented by regulating body weight, dieting, and exercising [9] and although obesity is preventable, the increase in body fat allows the progression of metabolic diseases

If GI symptoms are severe, the solution is slower dose titration (extending intervals between increases from 4 weeks to 68 weeks), eating smaller meals with lower fat content, and potentially adding ginger or vitamin B6 which have anti-nausea effects through different mechanisms

Bush JR, Wevrick R

Alternative GLP-1 formulations, dose adjustments, or switching to different weight loss medications may be appropriate

Increases energy for physical activity

In addition, variable comparators such as metformin or insulin have important differences, because insulin is known to cause weight gain