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It is plausible that the two siblings may carry different GLP1R genotypes: the sister might harbor the rs6923761 AA variant, which is associated with a higher weight loss rate, while the brother may carry the GG or GA variant that weakens semaglutide efficacy
Flohe L, Gunzler WA, Schock HH
Each developed symptoms after four to ten months on GLP-1s, with weight loss ranging from 8.2% to 18.7% of their baseline body weight
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