This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes
It should only be used in those with low thyroid function but you can pretty much guarantee that those with obesity have some level of thyroid dysfunction making it a great alternative
Poor sleep increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), directly undermining dietary adherence
Key variants in GLP1R (the GLP-1 receptor), GIPR (glucose-dependent insulinotropic peptide receptor), FTO (fat mass and obesity-associated gene), and MC4R (melanocortin 4 receptor) may affect medication sensitivity, baseline hunger signaling, and metabolic rate
Research in this area is ongoing
This success in obesity treatment has naturally led researchers to explore their potential in other metabolic disorders, including liver diseases like MASH