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BPC-157 modulates GABA pathways in rat models (Sikiri et al., 2010), the same system targeted by zolpidem, eszopiclone, and benzodiazepines

GLP-1 receptors are expressed in key brain regions including the hypothalamus, brainstem, and reward centers

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This is called titration

Cellular lipid ROS assay Lipid ROS levels were measured through oxidation of the C11-Bodipy lipid peroxidation sensor (Thermo Fisher Scientific) according to the manufacturers instructions

Elevated HbA1c promotes the intraerythrocytic generation of highly reactive free radicals (AGEs), which alter membrane functions and those of different cellular systems by binding to RAGE and producing cytokines and intracellular glyco-OS (Nuez-Musa, 2024)