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Lancet 375:14471456 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects
When to talk to a healthcare provider Only take GLP-1s alongside the guidance of a healthcare provider, and with regular touchpoints where you can talk to that provider about your symptoms
Most compounds can be used in impaired renal function
Tirzepatide tends to produce more intense gastrointestinal side effects, especially at higher doses
Appetite decreases through direct effects on hypothalamic hunger centers
Thats a decision for you and your doctor
