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The weight loss associated with metformin often plateaus because the medication does not activate GLP-1 receptors or suppress hunger hormones like peptide YY and cholecystokinin
Sinai Hospital, Toronto, Canada summarize and elucidate evidence that glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), initially developed for the treatment of type 2 diabetes and weight management, demonstrate a surprisingly broad range of clinical benefits
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So why are these medications helping us, even at these mini doses
Current evidence is preliminary and consists mainly of observational reports, case studies, and animal research rather than randomized controlled trials
Herringshaw is with the University of Massachusetts Chan Medical School in Worcester, Massachusetts
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