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This synergy operates through multiple mechanisms [7] : The REDEFINE 1 trial demonstrated that CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) produced 15.6% weight loss compared to 10.8% with cagrilintide alone and historical data of ~15% with semaglutide alone, suggesting true synergy [7]
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Vitamin B12 (Cobalamin) [Updated 2023 Jul 16]
Safety profile: Adverse effects are mainly GI, mild to moderate, and transientconsistent with GLP-1 profiles and most commonly involves nausea and constipation
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