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[40] The salvage pathways used in microorganisms differ from those of mammals
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Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms
Whilst weight loss is modest (typically 35% beyond lifestyle intervention), orlistat has an extensive safety record spanning over two decades
However, there are specific groups for which copper peptide serums may be best suited
1 Our lungs also have a high amount of glutathione
