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These potential cardioprotective effects may be related to the favourable actions of metformin on lipid metabolism, vascular smooth muscle, hypercoagulation, platelet hyperactivity, cardiomyocyte intracellular calcium handling and endothelial function [24]
It caused crazy hirsutism during that time
In pharmacology trials, GLP-1RA treatment has been shown to delay gastric emptying within the first postprandial hour [25, 28], although overall gastric emptying did not appear to be affected [28], suggesting additional mechanisms of action in GLP-1RA-mediated weight loss
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the related peptide afamelanotide (Scenesse) is FDA-approved for erythropoietic protoporphyria
This paradox may reflect a treatment landscape that appears complex and confusing, making it difficult for practitioners to identify the right drug for the right patient
