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Description

4-Pantetheinylation of formyltetrahydrofolate dehydrogenase (FDH) The figure shows two reactions involving FDH: Panel A: Holo-FDH (the biologically active FDH) catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate using water and NADP + , releasing CO 2 , NADPH, and a proton (H + )

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Pollizzi, K

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oral administration (less studied for musculoskeletal use) Typical dosing range: 200-500 mcg once or twice daily

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