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The GSHGPX4 antioxidant system in the mitochondria and cytoplasm is an important mechanism of cellular resistance to ferroptosis

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10.1111/j.1939-165X.2001.tb00434.x

Moreover our structure is likely to explain the considerable drop in hTrx1 activities upon disulphide formation between residues Cys62 hTrx1 and Cys69 hTrx1 (ref