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This suggests a trend towards reduced anxiety, which warrants further investigation with a larger sample size to achieve statistical power (Supplementary Fig

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Many are now FDA-approved for chronic weight management

Levels were also associated with traits related to muscle function, adiposity, glucose control, and longevity (right)

NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)

GLP-1/GIP receptor agonists work by supporting pathways involved in appetite signaling, digestion, nutrient utilization, and metabolic processes