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Expert Opin Ther Pat (2020) 30:78194

Nevertheless, personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN 2) represents an absolute contraindication to tirzepatide use

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In particular, changes in alcohol and nicotine use (both directly affecting sedation and recovery) may be more common than expected but not always captured in routine documentation

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