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Both groups experienced a significant reduction in their Movement Disorder Society Unified Parkinsons Disease Rating Scale (MDS-UPDRS) scores

Some studies showed prevention benefits even in the absence of metabolic changes.[ref][ref] Studies are showing positive effects on cognitive function and possibly reduced (or delayed) dementia with GLP-1s

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Muhammad Ghanem, a bariatric surgeon at Orlando Health Weight Loss and Bariatric Surgery Institute, shared in a separate interview with Fox News Digital that while some of his patients have reported mood changes, others "dont have that at all." FIRST GLP-1 PILL FOR WEIGHT LOSS, DIABETES SHOWS SUCCESS IN LATE-PHASE TRIAL "Depression or mood changes are very common regardless, especially nowadays, and so it's hard to [determine] whether this is related to the GLP-1 agonist medications, or whether it just happens to be that they started suffering from these after they started that medication," he said

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The ratio of target-receptor agonism can be manipulated to maximise efficacy whilst optimising adverse effects [31]