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The dual agonism of tirzepatide produces more pronounced appetite suppression and faster weight loss, which can lead to a more dramatic caloric deficit and potentially more acute fatigue during the initial adjustment period

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This is primarily to reduce the likelihood of gastrointestinal discomfort rather than to enhance absorption, and is consistent with the administration advice in the levocarnitine Summary of Product Characteristics (SmPC)

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Your starting tirzepatide dose is based on your current semaglutide dose, tolerability, and weight loss response