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In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

Moreover, L-carnitine has been found to aid in yet another crucial process - the release of triglycerides into the bloodstream

The original Ipamorelin literature characterized it as selective in GH secretagogue research and discussed pituitary hormone markers such as prolactin in the context of selectivity evaluation [3]

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More specifically, at the cellular level, Zeng et al