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Statistical controversies in clinical research: basket trials, umbrella trials, and other master protocols: a review and examples
Tang B, Xing Y, Li P, Zhang N, Yu F, Yang G
Xue XC, Wu YJ, Gao MT, Li WG, Zhao N, Wang ZL, et al
You can restrict calories all you want, but if your liver lacks the nutrients to process fat efficiently, your body stores what it should be burning
Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and cardiovascular disease and malignancy), these considerations may be outweighed, in older adults, by concerns regarding weight-loss induced reduction in skeletal muscle and bone mass, and the awareness of the obesity paradox
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