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The establishment, maintenance and characterization of midbrain organoids from human floor plate neuronal progenitor cells derived from a healthy (ID number: #232) and a Parkinsons disease patient with triplication in the SNCA gene (ID number: #317) were previously described by Muwanigwa et al

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doi: 10.3389/fimmu.2020.01748 51 DaiJ.WangY.WangH.GaoZ.WangY.FangM.et al

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Central to this is the excessive accumulation of ROS, which instigates lipid peroxidation, leading to extensive cellular and tissue damage [162, 163]