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The therapeutic potential of oral semaglutide once daily is being explored in two clinical trials, in populations with and without co-existing vascular disease, studying people at risk of developing Alzheimers disease (NCT04777396 and NCT04777409)
AEs were mild or moderate and attributed to gastrointestinal symptoms in 9/13 patients
Weight Loss and Waist Circumference Semaglutide: In major trials, participants achieved an average weight loss of around 15%
These drugs are well tolerated and reported hepatotoxicity is low in patients with mild and moderate liver function impairment
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