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This is due partly to cumulative effects of oxidative stress, which can damage DNA and impair oocyte viability

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The underlying illness influences the mortality rate which ranges from 10% in community-acquired cases to 90% in critically ill patients [134, 145]

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TGFBI hypermethylation in primary tumors is substantially associated with trastuzumab resistance in patients with HER2+ breast cancer [93]

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