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[6] As a consequence of its potential in digestive functioning, the peptide was hypothesized to increase appetite and weight gain

GDMT for HFrEF typically includes evidence-based beta-blockers, angiotensin receptor neprilysin inhibitors (ARNIs), angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, mineralocorticoid receptor antagonists (MRA), and sodium-glucose cotransporter 2 inhibitors (SGLT2is), particularly in patients with obesity or T2DM [53]

Without evidence from independent studies, its impossible to tell

Neurological and cardiovascular health*

Treatment discontinuation due to adverse event occurred in 4% to 11% of retatrutide-treated participants compared with 5% on placebo

Thats just how sodium works in a body thats already under stress