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Although the use of targeted metabolite tracing, such as deuterium tracing of NADPH [7], is successful and remains the gold standard in the field, this approach requires mass-spectrometry, which may not be accessible to many laboratories

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Researchers planning comparative studies should factor compound cost into budget planning, particularly for longer-duration protocols

In contrast, metformin works much faster

References Zheng Y, Ma AG, Zheng MC, Wang QZ, Liang H, Han XX, Schouten EG

But they arguably wouldn't be here if it wasn't for Eng's work which created the very first GLP-1 drug