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Study findings In humans, oral semaglutide is adequately absorbed when administered early in the morning in less than 120 mL water after overnight fasting and drinking-restricted state, followed by an additional fasting and drinking-restricted state of 30 minutes after taking the drug

Nausea, vomiting, and diarrhea are common early side effects of Ozempic, and they can lead to dehydration, which also means there is not enough fluid in the body to produce saliva properly

Help avoid any gastrointestinal symptoms while taking semaglutide, follow the doctors instructions carefully and talk to them about any dietary and lifestyle changes needed to make for managing the loss of fluids during episodes of diarrhea

95% CI, 0.31-0.83)

If you're weighing patches against other non-prescription options first, our broader article on GLP-1 weight loss patches cover the wider category

Patients should be counseled that while gastrointestinal side effects are common with weight loss injections, persistent or severe symptoms always warrant medical evaluation to rule out serious complications and ensure appropriate management