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To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration

Cell 183, 94109.e123

Mahmoud 40 reported that MTX was able to disturb the oxidant/anti-oxidant balance as indicated by increasing MDA level, decreasing GSH level and both SOD and CAT activities in the liver of rats

10 Finally, major surgery (eg, removal or replacement of all or part of the bladder, and/or rerouting of the urinary stream) can be effective but has a high complication rate and is a last option for those with severe, debilitating, intractable symptoms

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