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The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%

In patients with obesity and type 2 diabetes, carnitine supplementation improves insulin-induced glucose utilization and increases fatty acid oxidation rates

This means that GLP-1 therapies may gradually expand from specialist treatment settings to broader chronic disease management markets

But in someone with poor lymphatic clearance, endothelial leakiness, or chronic swelling, increasing blood flow without improving fluid clearance can sometimes worsen edema or pressure symptoms

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