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Um ensaio randomizado publicado no Journal of Clinical Endocrinology and Metabolism avaliou um secretagogo de GH oral em adultos mais velhos com limitao funcional leve e documentou elevao dose-dependente de IGF-1, ganho modesto de massa magra e melhora pontual de desempenho fsico mas o estudo foi encerrado precocemente e registrou eventos adversos como fadiga, insnia e pequenos aumentos de glicemia e de ndices de resistncia insulina

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2011;5(1):e35-48

Histological examination of skin sections with HE and Masson staining presented insights into the morphology of skin layers and collagen extent during the healing process (Figure 2)