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This suggests a potential disruption in cholesterol-bile acid metabolism, where cholesterol accumulation and reduced bile acid synthesis may trigger inflammatory responses and hepatocyte damage [62]

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Persistence is crucial, as it facilitates meeting and maintaining weight goals in a way that promotes healthy weight loss

According to the results from in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 (Wang et al., 2016)

Kido J, Inoue H, Shimotsu H et al (2020) Effect of L-carnitine on amino acid metabolism in elderly patients undergoing regular hemodialysis