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Divalproate: Six small placebo-controlled studies, N = 162, with low or very low confidence in the evidence (SMD: 0.51 (0.15-0.97) Atypical antipsychotics in monotherapy With moderate confidence in the evidence, four atypical antipsychotics were found efficacious in reducing depressive symptoms according to Yildiz al

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GLP-1 receptor agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) among them have become best known for two things: meaningful weight loss and better blood sugar control