Clinical score for the diagnosis of gout, adapted from Janssens et al
Furthermore, expression of GLP-1Rs have been demonstrated in astrocytes, microglia, and neurons in several important brain areas such as arcuate nucleus, paraventricular nucleus and dorsal medial nucleus of the hypothalamus (Cui et al
Neelakantan 2018 diet-induced obesity study
In a multi-receptor agonist, however, glucagon receptor activation occurs alongside GLP-1 and sometimes GIP receptor activation
Abbreviations DPP-4: Dipeptidyl peptidase-4 EMA: European Medicines Agency EPAC: Exchange protein directly activated by cAMP FDA: Food and Drug Administration FGF21: Fibroblast growth factor 21 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 PKA: Protein kinase A SGLT-2: Sodiumglucose cotransporter 2 References Moore B, Edie ES, Abram JS (1906) On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
Ryan Miller can be reached at [email protected]