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Acknowledgment The authors are grateful to Franois-Cyril Jolicoeur and Changshan Geng from the Osteoarthritis Research Unit of the CRCHUM for their expert technical assistance, as well as Virginia Wallis for assistance with manuscript preparation

Three out of 32 OA patients were considered treatment failures

Glutathione refines the immune system, detoxifies the liver, and supports overall well-being

Propionate is yet another important energy supply with an important function in the gluconeogenesis of PPCs, especially of the liver epithelial cells ( Faecalibacterium prausnitzii cannot be cultivated axenically in a medium without acetate (Rowland et al., 2018)

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However, factors like poor sleep, processed diets, and natural aging can deplete your internal stores