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Clinical trials have demonstrated cardiovascular benefits in certain patient populations, with Ozempic specifically indicated for reducing the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and Wegovy indicated for cardiovascular risk reduction in adults with established cardiovascular disease who have either obesity or overweight

Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with obesity or overweight (VISTA): A multicentre, phase 2, randomised, placebo-controlled clinical trial

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Patience during titration often yields better long-term adherence and outcomes

Consuming large, high-fat meals shortly after starting Ozempic often precipitates or worsens nausea and abdominal discomfort due to delayed gastric emptying

In that scenario, the FDA could remove semaglutide from the shortage list even though patients experience access delays