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Ultimately, Pfizer discontinued the entire program in April 2025, citing that the risk-benefit profile, including a potential case of drug-induced liver injury (DILI) in a recent study, did not support further development

Critical revision of the manuscript for important intellectual content: IAM, FWB, and SK

in contrast, the 4 mg dose of efpeglenatide had no statistically significant effect on HF hospitalisation

Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis

GLP-1

These are spontaneously reported adverse events in a mixed diabetic and non-diabetic cohort, not measured glycaemia, and most of that placebo excess is almost certainly untreated disease progression rather than anything the drug did