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( e ) Schematic of AKP organoid isolation and culture (3D and 2D cell line) with representative images of 3D or 2D cultures treated 5FU at 72 h

M., & Agarwal, V

Adv Ther 37(7):3112-3128, 2020

5-HTP (i) is the direct rate-limiting precursor of serotonin, (ii) potently amplifies serotonin synthesis, (iii) has minimal off-target, and (iv) has a favorable human safety record (7, 32, 49, 55)