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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner

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Metabolism and Cellular Bioenergetics NNMT activity is closely linked to nicotinamide metabolism, an important component of the NAD

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