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Melanocytes from vitiligo patients suffer from excess reactive oxygen species (ROS) produced by defective mitochondria besides a poor endogenous antioxidant system (EAS) ( Vitiligo severity has also been associated with metabolic syndrome (MetS), increasing the prevalence and incidence of MetS or associated disorders such as insulin resistance and hypercholesterolemia (Sharma et al., 2017

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Yet, matrix biology is multi-layered, and signals can vary by cell source, assay format, and time point