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Infusion of exendin-4 into that nucleus reduced nicotine taking (Tuesta et al., 2017), and the habenular circuit is the same one that limits nicotine intake through aversion (Fowler et al., 2011)
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For patients and clinicians, the practical message is reassuring: retatrutide has not been associated with increased risk of pancreatitis or liver injury in studies so far, and gallbladder events appear rare and manageable
Around 5,000 positions are expected to be cut in Denmark
Retatrutide is an investigational GIP, GLP-1, and glucagon receptor triple agonist without current MHRA approval
