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In the highest-risk patient subset, those with triglycerides above 880mg/dL and a prior history of pancreatitis, plozasiran produced a 100 percent reduction in acute pancreatitis events versus placebo

While selection and safety establish who to treat and how to minimize risks, response biomarkers evaluate whether the intervention produces meaningful benefit, mirroring how preclinical glial modulation must be validated through functional readouts

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The GLP-1 and GIP arms slow gastric emptying and blunt appetite (that is where nausea comes from), while the glucagon arm nudges energy expenditure and hepatic fat handling