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Key finding: AOD 9604 reduced body weight by 5.4 kg, reduced fasting glucose by 23 mg/dL, and improved HbA1c by 0.6%

In Phase 2 trial imaging, fat mass fell substantially more than lean mass, so most of the weight lost was fat the muscle loss is real but is a minority of total loss and is in the same range as semaglutide and tirzepatide

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As a water soluable vitamin, youll simply pee out the excess

Changes in NNMT activity shouldnt be interpreted as producing predictable changes in NAD+ levels across all biological systems