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Sudden worsening of nausea after initially improving may indicate a medication interaction, underlying gastrointestinal condition, or dose-related issue that needs adjustment

"[now] I can maybe do one or two light beers, and that's it, whereas before, I could drink, like, five IPAs in a sitting, so I definitely drink a lot less." Most participants reduced their alcohol intake as a result of taking weight loss drugs Change in alcohol consumption "I used to really drink a lot of beer," Ella reminisces

Future translational efforts should pursue several directions: first, conducting deep-phenotyping trials in biopsy-confirmed MASH patients, using positron emission tomography to quantify hepatic glucose uptake and correlating these findings with intrahepatic insulin signaling (e.g., p-AKT)

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Loguercio, C., & Di Pierro, M

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