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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

Researchers should handle Agomelatine with care and adhere to strict safety guidelines during experiments

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Daily dosing at higher amounts may require additional supply for longer cycles

This modulatory role, which is distinct from its metabolic function, adds another layer of complexity to the interpretation of neurovascular coupling and may contribute to the BOLD signal [195]

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