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Studies by others indicate that ILK can stabilize microtubules at the cell surface of keratinocytes by recruiting the scaffolding protein IQGAP and one of its effectors, mDia [51], previously shown to stabilize microtubules downstream of integrin engagement (Fig

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In Ewing sarcoma cells with constitutive nuclear IGF-1R, treatment with the kinase inhibitor Linsitinib reduced the level of ubiquitinated-PCNA, thus likely attenuating DDT [132]