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Bowel obstructions were reported in 0.8% of Saxenda users, versus 0.17% for Contrave
10.1016/j.freeradbiomed.2007.11.014 72
However, unlike the natural hormone, which breaks down in minutes, agonists are chemically modified to resist degradation, allowing them to remain active in the body for hours or days to provide continuous metabolic control
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Leptin, however, has never been useful in the treatment of obesity, even in individuals who are leptin deficient
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