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GLP-1 RAs may provide additional therapeutic benefits beyond glycemic control due to their multifaceted metabolic and anti-inflammatory properties

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Concerning BW, a higher baseline BMI predicts absolute weight reduction

Most included studies also had relatively short follow-up durations, limiting robust long-term assessments of sustained weight loss and remission of obesity-related comorbidities

However, improved metabolic health from GLP-1 therapy may actually enhance ovulation and fertility outcomes in women with insulin-resistant PCOSa nuance worth exploring with a reproductive endocrinologist or primary care provider

In adipose tissue, elevated NNMT activity is strongly correlated with obesity, insulin resistance, and cellular aging