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Advanced monitoring techniquessuch as electron paramagnetic resonance (EPR) for real-time ROS detection and mitochondrial DNA copy number assayscan enhance endpoint precision, as piloted in the MITO-HTN study (Rossman et al., 2018)

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Currently, there is only two classes of drugs approved for the treatment of AD: N-methyl D -aspartate (NMDA) antagonist (memantine), and cholinesterase inhibitors (tacrine, Donepezil, galantamine, rivastigmine)

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The NHS adult daily requirement is 1.5 micrograms a day, which a normal mixed diet covers easily and stores in the liver for years