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Energy buffering systems, including phosphocreatine (PCr), inorganic phosphate (Pi), and creatine, are also altered across brain regions in MDD and correlate with symptom severity [63,64,65]

Heterogeneity was assessed using the I 2 statistic and Cochrans Q test

Previous research suggests DSIP can influence biosynthetic processes in the brain, reduce stress protein factors, and potentially affect glutamate and GABA receptors in regions like the cortex, thalamus, and hippocampus

the rulemaking process may be delayed, modified, or not completed

It does not directly enhance desire

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