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Production of PIP 3 enables phosphorylation of Akt at threonine 308 (T308) by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and at serine 473 (S473) by the mechanistic target of rapamycin complex 2 (mTORC2)

Dietary Support: Foods rich in sulfur (like garlic, onions, broccoli, and eggs) can naturally boost glutathione production

Additionally, metformin has been shown to upregulate the expression of GLUT4 in endometrial cells of patients with PCOS, thereby inhibiting the progression of EC (Li et al., 2023)