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Oral administration of allicin to mice lowered ROS production and prevented ROS-induced cardiac hypertrophy by inhibiting pro-inflammatory pathways like mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/glycogen synthase kinase 3 (GSK3) signaling pathways (20)
After undergoing extensive preclinical optimization and multiple successful clinical phases globally and in China, mazdutide received marketing approval in China in June 2025 under the brand name Xinermei, becoming the first domestically approved dual GLP-1/glucagon receptor agonist for weight management and glycemic control
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This reduction likely results from glucagon-mediated enhancement of hepatic LDL receptor expression and increased cholesterol catabolism through bile acid synthesis
& Tibbs, G
