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GLP-1-RAs and metabolic adaptation Metabolic adaptation is the difference between the observed resting energy expenditure and the estimated resting energy expenditure post-weight loss [51]

doi: 10.1038/s41392-024-01933-x 33 LibertiMVLocasaleJW

Most weight lost with GLP-1/GIP therapy is fat , and overall body composition improves

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After the titration phase, rates may slow as your body weight decreases and adaptation occurs